Drug interactions
Oxymorphone + Selegiline
Severity: Major
Oxymorphone and Selegiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor that loses selectivity at higher doses, notably with the transdermal form. Opioids with MAOIs have been linked to hypotension, CNS depression and serotonergic reactions, and oxymorphone labeling advises avoiding use with MAOIs.
What this interaction means in plain words
Oxymorphone and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxymorphone belongs to Musculoskeletal; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition, with loss of selectivity at higher doses, may potentiate opioid CNS and autonomic effects.
What to do
Avoid the combination where possible and use an alternative analgesic. If an opioid is essential, start at a low dose and monitor sedation, blood pressure and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Oxymorphone with Selegiline?
MediHelp rates the interaction as major. Oxymorphone and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline is an MAO-B inhibitor that loses selectivity at higher doses, notably with the transdermal form. Opioids with MAOIs have been linked to hypotension, CNS depression and serotonergic reactions, and oxymorphone labeling advises avoiding use with MAOIs.
How serious is the interaction between Oxymorphone and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative analgesic. If an opioid is essential, start at a low dose and monitor sedation, blood pressure and signs of serotonin toxicity.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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