Drug interactions
Oxymorphone + Suvorexant
Severity: Moderate
Oxymorphone and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant with an opioid adds sedation and may impair next-day alertness and coordination. The combination increases the risk of falls and respiratory depression.
What this interaction means in plain words
Oxymorphone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and opioid agonism.
What to do
Use the lowest effective doses and consider reducing suvorexant. Counsel about driving and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Oxymorphone with Suvorexant?
MediHelp rates the interaction as moderate. Oxymorphone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant with an opioid adds sedation and may impair next-day alertness and coordination. The combination increases the risk of falls and respiratory depression.
How serious is the interaction between Oxymorphone and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider reducing suvorexant. Counsel about driving and monitor for oversedation.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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