Drug interactions
Oxytocin + Pseudoephedrine
Severity: Moderate
Oxytocin and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxytocin can cause hypotension at times, while vasopressors may cause marked hypertension when given after it. Combining a sympathomimetic with oxytocin may theoretically intensify pressor effects, but clinical data for pseudoephedrine specifically are limited.
What this interaction means in plain words
Oxytocin and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxytocin belongs to Endocrine; Pseudoephedrine belongs to Respiratory.
Why it happens
Additive pharmacodynamic cardiovascular effects; the mechanism for this specific pair is not well established.
What to do
Avoid pseudoephedrine in obstetric patients receiving oxytocin when possible; if needed, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Frequently asked questions
Can I take Oxytocin with Pseudoephedrine?
MediHelp rates the interaction as moderate. Oxytocin and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxytocin can cause hypotension at times, while vasopressors may cause marked hypertension when given after it. Combining a sympathomimetic with oxytocin may theoretically intensify pressor effects, but clinical data for pseudoephedrine specifically are limited.
How serious is the interaction between Oxytocin and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pseudoephedrine in obstetric patients receiving oxytocin when possible; if needed, monitor blood pressure and heart rate closely.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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