Drug interactions
Paclitaxel + Pazopanib
Severity: Moderate
Paclitaxel and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits CYP3A4, CYP2C8 and P-glycoprotein and has been shown to increase paclitaxel exposure. This can intensify neutropenia and other toxicity.
What this interaction means in plain words
Paclitaxel and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Pazopanib inhibits CYP2C8/3A4 and P-glycoprotein, decreasing paclitaxel clearance.
What to do
Monitor blood counts and neuropathy closely and reduce paclitaxel dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Paclitaxel with Pazopanib?
MediHelp rates the interaction as moderate. Paclitaxel and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits CYP3A4, CYP2C8 and P-glycoprotein and has been shown to increase paclitaxel exposure. This can intensify neutropenia and other toxicity.
How serious is the interaction between Paclitaxel and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy closely and reduce paclitaxel dose as needed.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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