Drug interactions
Paclitaxel + Pioglitazone
Severity: Minor
Paclitaxel and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized partly by CYP2C8, which pioglitazone can inhibit weakly in vitro. In clinical use no meaningful rise in paclitaxel exposure has been established.
What this interaction means in plain words
Paclitaxel and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Pioglitazone belongs to Endocrine.
Why it happens
Possible weak CYP2C8 inhibition by pioglitazone reducing paclitaxel clearance.
What to do
No dose change is needed. Monitor for neutropenia and neuropathy as routine with paclitaxel.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paclitaxel and Pioglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pioglitazone
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Pioglitazone?
MediHelp rates the interaction as minor. Paclitaxel and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is metabolized partly by CYP2C8, which pioglitazone can inhibit weakly in vitro. In clinical use no meaningful rise in paclitaxel exposure has been established.
How serious is the interaction between Paclitaxel and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for neutropenia and neuropathy as routine with paclitaxel.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
