Drug interactions
Paclitaxel + Primidone
Severity: Moderate
Paclitaxel and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, an inducer of CYP2C8 and CYP3A4, and may lower paclitaxel exposure. This could reduce antitumor efficacy.
What this interaction means in plain words
Paclitaxel and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Primidone belongs to Central Nervous System.
Why it happens
Enzyme induction by primidone and its phenobarbital metabolite increases paclitaxel metabolism.
What to do
Prefer a non-inducing antiseizure drug; if continued, monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Paclitaxel with Primidone?
MediHelp rates the interaction as moderate. Paclitaxel and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital, an inducer of CYP2C8 and CYP3A4, and may lower paclitaxel exposure. This could reduce antitumor efficacy.
How serious is the interaction between Paclitaxel and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug; if continued, monitor tumor response.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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