Drug interactions
Paclitaxel + Quinine
Severity: Minor
Paclitaxel and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4, and quinine's inhibitory effect on these enzymes is weak and poorly documented. Any increase in paclitaxel exposure would raise the risk of neutropenia and neuropathy, but the clinical significance is uncertain.
What this interaction means in plain words
Paclitaxel and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP3A4/CYP2C8 metabolism of paclitaxel by quinine.
What to do
No routine change needed; monitor blood counts and neuropathy symptoms as for standard paclitaxel therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Quinine?
MediHelp rates the interaction as minor. Paclitaxel and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and quinine's inhibitory effect on these enzymes is weak and poorly documented. Any increase in paclitaxel exposure would raise the risk of neutropenia and neuropathy, but the clinical significance is uncertain.
How serious is the interaction between Paclitaxel and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; monitor blood counts and neuropathy symptoms as for standard paclitaxel therapy.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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