Drug interactions
Paclitaxel + Selpercatinib
Severity: Major
Paclitaxel and Selpercatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can increase paclitaxel exposure because paclitaxel is cleared substantially via CYP2C8. This may worsen neutropenia and peripheral neuropathy.
What this interaction means in plain words
Paclitaxel and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Paclitaxel belongs to Oncology; Selpercatinib belongs to Oncology.
Why it happens
Selpercatinib inhibits CYP2C8-mediated metabolism of paclitaxel.
What to do
Avoid concurrent use if possible. If needed, monitor blood counts and neuropathy and reduce the paclitaxel dose as clinically indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paclitaxel and Selpercatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Selpercatinib
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Selpercatinib?
MediHelp rates the interaction as major. Paclitaxel and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib can increase paclitaxel exposure because paclitaxel is cleared substantially via CYP2C8. This may worsen neutropenia and peripheral neuropathy.
How serious is the interaction between Paclitaxel and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If needed, monitor blood counts and neuropathy and reduce the paclitaxel dose as clinically indicated.
What other medicines interact with Selpercatinib?
MediHelp also lists interactions of Selpercatinib with, for example, Amiodarone, Amisulpride, Amitriptyline. The full list is on the Selpercatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
