Drug interactions
Paclitaxel protein bound + Ribociclib
Severity: Moderate
Paclitaxel protein bound and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4, and inhibition of CYP3A4 may raise exposure. Ribociclib may increase paclitaxel levels, and both agents cause neutropenia, so myelosuppression may be additive.
What this interaction means in plain words
Paclitaxel protein bound and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by ribociclib reduces paclitaxel clearance, with overlapping myelosuppression.
What to do
Monitor blood counts and neuropathy regularly, and reduce or delay doses for severe neutropenia or neurotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Ribociclib?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and inhibition of CYP3A4 may raise exposure. Ribociclib may increase paclitaxel levels, and both agents cause neutropenia, so myelosuppression may be additive.
How serious is the interaction between Paclitaxel protein bound and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy regularly, and reduce or delay doses for severe neutropenia or neurotoxicity.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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