Drug interactions
Paclitaxel protein bound + Voriconazole
Severity: Moderate
Paclitaxel protein bound and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4, so voriconazole may increase exposure. This could worsen neutropenia and peripheral neuropathy, although the contribution of CYP3A4 is partial.
What this interaction means in plain words
Paclitaxel protein bound and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by voriconazole may reduce paclitaxel clearance.
What to do
Monitor blood counts and neuropathy symptoms closely, and reduce the paclitaxel dose if toxicity develops. Consider an alternative antifungal if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Voriconazole?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is metabolized by CYP2C8 and CYP3A4, so voriconazole may increase exposure. This could worsen neutropenia and peripheral neuropathy, although the contribution of CYP3A4 is partial.
How serious is the interaction between Paclitaxel protein bound and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms closely, and reduce the paclitaxel dose if toxicity develops. Consider an alternative antifungal if possible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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