Drug interactions
Palifermin + Procarbazine
Severity: Moderate
Palifermin and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to cytotoxic chemotherapy may worsen the severity and duration of oral mucositis, probably because it stimulates proliferation of rapidly dividing epithelial cells that are then exposed to chemotherapy.
What this interaction means in plain words
Palifermin and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palifermin belongs to Miscellaneous; Procarbazine belongs to Oncology.
Why it happens
Palifermin-stimulated epithelial proliferation may increase susceptibility to cytotoxic damage when chemotherapy is given nearby.
What to do
Do not give palifermin within 24 hours before, during, or 24 hours after procarbazine-containing chemotherapy. Monitor for mucositis if timing overlaps.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Procarbazine?
MediHelp rates the interaction as moderate. Palifermin and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given close to cytotoxic chemotherapy may worsen the severity and duration of oral mucositis, probably because it stimulates proliferation of rapidly dividing epithelial cells that are then exposed to chemotherapy.
How serious is the interaction between Palifermin and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or 24 hours after procarbazine-containing chemotherapy. Monitor for mucositis if timing overlaps.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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