Drug interactions
Palifermin + Vinblastine
Severity: Major
Palifermin and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth and given close to chemotherapy can worsen mucositis, since proliferating cells are more sensitive to cytotoxic drugs. Labeling advises separating palifermin from chemotherapy.
What this interaction means in plain words
Palifermin and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palifermin belongs to Miscellaneous; Vinblastine belongs to Oncology.
Why it happens
Palifermin-induced epithelial proliferation increases susceptibility of mucosal cells to cytotoxic damage.
What to do
Do not give palifermin within 24 hours before, during or after vinblastine. Follow the labeled schedule for administration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinblastine
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Vinblastine?
MediHelp rates the interaction as major. Palifermin and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin stimulates epithelial cell growth and given close to chemotherapy can worsen mucositis, since proliferating cells are more sensitive to cytotoxic drugs. Labeling advises separating palifermin from chemotherapy.
How serious is the interaction between Palifermin and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during or after vinblastine. Follow the labeled schedule for administration.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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