Drug interactions
Paliperidone + Papaveretum
Severity: Moderate
Paliperidone and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, so with paliperidone it can intensify sedation, lower blood pressure and depress breathing.
What this interaction means in plain words
Paliperidone and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedation.
What to do
Use the lowest effective opioid dose and monitor sedation, respiratory rate and blood pressure. Avoid additional sedatives and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Papaveretum?
MediHelp rates the interaction as moderate. Paliperidone and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opium alkaloids including morphine, so with paliperidone it can intensify sedation, lower blood pressure and depress breathing.
How serious is the interaction between Paliperidone and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation, respiratory rate and blood pressure. Avoid additional sedatives and alcohol.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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