Drug interactions
Paliperidone + Quazepam
Severity: Moderate
Paliperidone and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic, and combining it with paliperidone can increase sedation, dizziness and psychomotor impairment. Respiratory depression and falls are a concern, particularly in older adults.
What this interaction means in plain words
Paliperidone and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and dopamine/histamine/alpha-adrenergic antagonism.
What to do
Use the lowest effective quazepam dose and monitor for excess sedation, hypotension and falls. Advise against driving or other hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Quazepam?
MediHelp rates the interaction as moderate. Paliperidone and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic, and combining it with paliperidone can increase sedation, dizziness and psychomotor impairment. Respiratory depression and falls are a concern, particularly in older adults.
How serious is the interaction between Paliperidone and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective quazepam dose and monitor for excess sedation, hypotension and falls. Advise against driving or other hazardous tasks.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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