Drug interactions
Paliperidone + Romidepsin
Severity: Major
Paliperidone and Romidepsin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with QT/T-wave changes, and paliperidone also prolongs QTc. Using both may increase arrhythmia risk, especially with low potassium or magnesium.
What this interaction means in plain words
Paliperidone and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider an alternative antipsychotic. If both are needed, check baseline ECG and keep potassium and magnesium replete throughout treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Romidepsin?
MediHelp rates the interaction as major. Paliperidone and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin has been associated with QT/T-wave changes, and paliperidone also prolongs QTc. Using both may increase arrhythmia risk, especially with low potassium or magnesium.
How serious is the interaction between Paliperidone and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antipsychotic. If both are needed, check baseline ECG and keep potassium and magnesium replete throughout treatment.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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