Drug interactions
Paliperidone + Sufentanil sl
Severity: Major
Paliperidone and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with an antipsychotic that has sedating and hypotensive properties can add to central nervous system and respiratory depression. Profound sedation, low blood pressure, coma and death have been reported with opioid and CNS depressant combinations.
What this interaction means in plain words
Paliperidone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS and respiratory depression, with additive hypotensive effects from alpha-adrenergic blockade by paliperidone.
What to do
Use together only if no alternatives exist, with the lowest effective doses and shortest duration. Monitor for sedation, respiratory depression and hypotension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Sufentanil sl?
MediHelp rates the interaction as major. Paliperidone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with an antipsychotic that has sedating and hypotensive properties can add to central nervous system and respiratory depression. Profound sedation, low blood pressure, coma and death have been reported with opioid and CNS depressant combinations.
How serious is the interaction between Paliperidone and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only if no alternatives exist, with the lowest effective doses and shortest duration. Monitor for sedation, respiratory depression and hypotension.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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