Drug interactions
Paliperidone + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Paliperidone and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can prolong QTc and cause tachycardia or hypokalemia, and paliperidone also prolongs QTc. Systemic exposure from inhalation is low, so the effect is usually modest but may matter in patients with cardiac risk factors.
What this interaction means in plain words
Paliperidone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT-prolonging effects, with beta-agonist-induced hypokalemia and sympathetic stimulation adding to arrhythmia risk.
What to do
Use at the labeled dose and monitor ECG and potassium in patients with QT risk factors. Avoid the combination in those with known long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Paliperidone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can prolong QTc and cause tachycardia or hypokalemia, and paliperidone also prolongs QTc. Systemic exposure from inhalation is low, so the effect is usually modest but may matter in patients with cardiac risk factors.
How serious is the interaction between Paliperidone and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at the labeled dose and monitor ECG and potassium in patients with QT risk factors. Avoid the combination in those with known long QT syndrome.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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