Drug interactions
Paliperidone + Yohimbine
Severity: Moderate
Paliperidone and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant and anxiety-provoking effects that may partly counteract paliperidone's sedation, while it may also worsen agitation or psychosis. It can also raise blood pressure and heart rate, and the net clinical effect is unpredictable.
What this interaction means in plain words
Paliperidone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects: alpha-2 blockade with noradrenergic stimulation versus dopamine and alpha-1 antagonism.
What to do
Avoid yohimbine in patients with psychotic disorders where possible. If both are used, monitor blood pressure, heart rate and psychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Yohimbine?
MediHelp rates the interaction as moderate. Paliperidone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist with stimulant and anxiety-provoking effects that may partly counteract paliperidone's sedation, while it may also worsen agitation or psychosis. It can also raise blood pressure and heart rate, and the net clinical effect is unpredictable.
How serious is the interaction between Paliperidone and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine in patients with psychotic disorders where possible. If both are used, monitor blood pressure, heart rate and psychiatric symptoms.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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