Drug interactions
Palovarotene + Sertraline
Severity: Minor
Palovarotene and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is metabolized by CYP3A4, and sertraline is only a weak inhibitor, so a significant increase in exposure is unlikely. Excess palovarotene exposure could increase retinoid toxicity such as mucocutaneous effects and premature epiphyseal closure.
What this interaction means in plain words
Palovarotene and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Palovarotene belongs to Miscellaneous; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly reduce palovarotene clearance.
What to do
No dose adjustment is generally needed with a weak inhibitor. Monitor for retinoid adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Palovarotene with Sertraline?
MediHelp rates the interaction as minor. Palovarotene and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palovarotene is metabolized by CYP3A4, and sertraline is only a weak inhibitor, so a significant increase in exposure is unlikely. Excess palovarotene exposure could increase retinoid toxicity such as mucocutaneous effects and premature epiphyseal closure.
How serious is the interaction between Palovarotene and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed with a weak inhibitor. Monitor for retinoid adverse effects.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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