Drug interactions
Palovarotene + Verapamil
Severity: Major
Palovarotene and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a moderate CYP3A4 inhibitor, can raise palovarotene exposure and increase retinoid-related toxicity such as mucocutaneous effects, and premature epiphyseal closure risk in children.
What this interaction means in plain words
Palovarotene and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palovarotene belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of palovarotene by verapamil.
What to do
Avoid the combination where possible. If it is unavoidable, reduce the palovarotene dose as per labeling and monitor for retinoid adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Palovarotene with Verapamil?
MediHelp rates the interaction as major. Palovarotene and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil, a moderate CYP3A4 inhibitor, can raise palovarotene exposure and increase retinoid-related toxicity such as mucocutaneous effects, and premature epiphyseal closure risk in children.
How serious is the interaction between Palovarotene and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is unavoidable, reduce the palovarotene dose as per labeling and monitor for retinoid adverse effects.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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