Drug interactions
Pancuronium + Primidone
Severity: Minor
Pancuronium and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term primidone, partly metabolized to phenobarbital, may reduce the response to pancuronium. Patients may recover faster or need larger doses.
What this interaction means in plain words
Pancuronium and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pancuronium belongs to Musculoskeletal; Primidone belongs to Central Nervous System.
Why it happens
Induction of hepatic enzymes and possible resistance to non-depolarizing blockers with chronic anticonvulsant use; mechanism not fully established.
What to do
Use train-of-four monitoring and adjust pancuronium dose to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pancuronium
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Pancuronium with Primidone?
MediHelp rates the interaction as minor. Pancuronium and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term primidone, partly metabolized to phenobarbital, may reduce the response to pancuronium. Patients may recover faster or need larger doses.
How serious is the interaction between Pancuronium and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use train-of-four monitoring and adjust pancuronium dose to effect.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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