Drug interactions
Pantoprazole + Pexidartinib
Severity: Major
Pantoprazole and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib absorption falls when gastric acidity is reduced. Pantoprazole can therefore lower pexidartinib exposure and reduce efficacy in tenosynovial giant cell tumor.
What this interaction means in plain words
Pantoprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pantoprazole belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Increased gastric pH decreases the solubility and absorption of pexidartinib.
What to do
Avoid proton pump inhibitors. If needed, use a locally acting antacid taken 2 hours before or after pexidartinib, or an H2 antagonist with pexidartinib taken at least 2 hours before or 10 hours after it.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pantoprazole with Pexidartinib?
MediHelp rates the interaction as major. Pantoprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib absorption falls when gastric acidity is reduced. Pantoprazole can therefore lower pexidartinib exposure and reduce efficacy in tenosynovial giant cell tumor.
How serious is the interaction between Pantoprazole and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid proton pump inhibitors. If needed, use a locally acting antacid taken 2 hours before or after pexidartinib, or an H2 antagonist with pexidartinib taken at least 2 hours before or 10 hours after it.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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