Drug interactions
Pantoprazole + Regorafenib
Severity: Minor
Pantoprazole and Regorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP, and pantoprazole is a BCRP substrate, so pantoprazole exposure could rise slightly. Clinical consequences are unlikely given pantoprazole's wide safety margin.
What this interaction means in plain words
Pantoprazole and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pantoprazole belongs to Gastrointestinal Tract; Regorafenib belongs to Oncology.
Why it happens
Possible BCRP inhibition by regorafenib reduces pantoprazole efflux.
What to do
No dose change is generally needed; monitor for pantoprazole adverse effects such as headache or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Regorafenib
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Pantoprazole with Regorafenib?
MediHelp rates the interaction as minor. Pantoprazole and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit BCRP, and pantoprazole is a BCRP substrate, so pantoprazole exposure could rise slightly. Clinical consequences are unlikely given pantoprazole's wide safety margin.
How serious is the interaction between Pantoprazole and Regorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for pantoprazole adverse effects such as headache or diarrhea.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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