Drug interactions
Pantoprazole + Selexipag
Severity: Minor
Pantoprazole and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole may inhibit BCRP (ABCG2), a transporter that handles selexipag, and could modestly raise exposure to it. This might increase prostacyclin-type adverse effects such as headache, diarrhea, nausea and jaw pain.
What this interaction means in plain words
Pantoprazole and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pantoprazole belongs to Gastrointestinal Tract; Selexipag belongs to Cardiovascular.
Why it happens
Possible inhibition of BCRP-mediated efflux of selexipag by pantoprazole.
What to do
Monitor for increased selexipag adverse effects and adjust the dose according to tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Pantoprazole with Selexipag?
MediHelp rates the interaction as minor. Pantoprazole and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pantoprazole may inhibit BCRP (ABCG2), a transporter that handles selexipag, and could modestly raise exposure to it. This might increase prostacyclin-type adverse effects such as headache, diarrhea, nausea and jaw pain.
How serious is the interaction between Pantoprazole and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased selexipag adverse effects and adjust the dose according to tolerability.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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