Drug interactions
Pantoprazole + Sparsentan
Severity: Moderate
Pantoprazole and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan exposure may fall when gastric acidity is reduced, potentially weakening its effect on proteinuria in IgA nephropathy. The interaction is largely predicted from solubility behavior.
What this interaction means in plain words
Pantoprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pantoprazole belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Higher gastric pH may reduce sparsentan solubility and absorption.
What to do
Monitor proteinuria and blood pressure response, and use the lowest effective acid suppression or consider an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Pantoprazole with Sparsentan?
MediHelp rates the interaction as moderate. Pantoprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan exposure may fall when gastric acidity is reduced, potentially weakening its effect on proteinuria in IgA nephropathy. The interaction is largely predicted from solubility behavior.
How serious is the interaction between Pantoprazole and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor proteinuria and blood pressure response, and use the lowest effective acid suppression or consider an alternative.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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