Drug interactions
Papaveretum + Pentazocine
Severity: Major
Papaveretum and Pentazocine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids such as morphine, which pentazocine may antagonise. This can reduce analgesia and precipitate withdrawal in opioid-dependent patients, while sedation and respiratory depression may be additive.
What this interaction means in plain words
Papaveretum and Pentazocine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mixed agonist-antagonist competes with full mu agonists and adds CNS depression.
What to do
Avoid concurrent use. If unavoidable, monitor for withdrawal, pain control and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Papaveretum with Pentazocine?
MediHelp rates the interaction as major. Papaveretum and Pentazocine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids such as morphine, which pentazocine may antagonise. This can reduce analgesia and precipitate withdrawal in opioid-dependent patients, while sedation and respiratory depression may be additive.
How serious is the interaction between Papaveretum and Pentazocine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If unavoidable, monitor for withdrawal, pain control and respiratory depression.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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