Drug interactions
Papaveretum + Perphenazine
Severity: Major
Papaveretum and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, which cause CNS and respiratory depression. Together with perphenazine, sedation and hypotension are potentiated, with risk of respiratory compromise.
What this interaction means in plain words
Papaveretum and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and phenothiazine sedation.
What to do
Use reduced opioid doses and monitor respiratory rate, sedation and blood pressure. Avoid additional CNS depressants.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Papaveretum with Perphenazine?
MediHelp rates the interaction as major. Papaveretum and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine, which cause CNS and respiratory depression. Together with perphenazine, sedation and hypotension are potentiated, with risk of respiratory compromise.
How serious is the interaction between Papaveretum and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced opioid doses and monitor respiratory rate, sedation and blood pressure. Avoid additional CNS depressants.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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