Drug interactions
Papaverine + Pimozide
Severity: Moderate
Papaverine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine is a smooth muscle relaxant with a mild sedative effect at most. Evidence of a relevant additive sedation is weak, but papaverine has been associated with QT prolongation and may add to pimozide's cardiac risk.
What this interaction means in plain words
Papaverine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Papaverine belongs to Cardiovascular; Pimozide belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation and mild CNS effects; the mechanism is not firmly established.
What to do
Check the ECG and keep potassium and magnesium normal if the combination is needed. Monitor for dizziness, syncope and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Papaverine and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Pimozide?
MediHelp rates the interaction as moderate. Papaverine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaverine is a smooth muscle relaxant with a mild sedative effect at most. Evidence of a relevant additive sedation is weak, but papaverine has been associated with QT prolongation and may add to pimozide's cardiac risk.
How serious is the interaction between Papaverine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and keep potassium and magnesium normal if the combination is needed. Monitor for dizziness, syncope and palpitations.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
