Drug interactions
Papaverine + Triclofos
Severity: Minor
Papaverine and Triclofos: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol. Papaverine may slightly add to sedation, although the interaction is largely theoretical.
What this interaction means in plain words
Papaverine and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; papaverine's contribution is weak.
What to do
Monitor for excessive drowsiness, especially in children and older adults, and keep the triclofos dose at the lowest effective level.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Triclofos?
MediHelp rates the interaction as minor. Papaverine and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclofos is a sedative-hypnotic prodrug of trichloroethanol. Papaverine may slightly add to sedation, although the interaction is largely theoretical.
How serious is the interaction between Papaverine and Triclofos?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, especially in children and older adults, and keep the triclofos dose at the lowest effective level.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Papaverine page.
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