Drug interactions
Papaverine + Trifluoperazine
Severity: Minor
Papaverine and Trifluoperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is a phenothiazine antipsychotic that can cause sedation and orthostatic hypotension. Papaverine may add slightly to these effects, though the interaction is expected to be small.
What this interaction means in plain words
Papaverine and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression and vasodilatory hypotension; weak and poorly characterized.
What to do
Monitor for drowsiness and orthostatic hypotension, especially at treatment initiation. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Trifluoperazine?
MediHelp rates the interaction as minor. Papaverine and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trifluoperazine is a phenothiazine antipsychotic that can cause sedation and orthostatic hypotension. Papaverine may add slightly to these effects, though the interaction is expected to be small.
How serious is the interaction between Papaverine and Trifluoperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and orthostatic hypotension, especially at treatment initiation. No routine dose change is needed.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Papaverine page.
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