Drug interactions
Paracetamol + Pexidartinib
Severity: Moderate
Paracetamol and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Paracetamol is a recognized dose-dependent hepatotoxin, so combining them may add to hepatic risk, particularly at higher paracetamol doses.
What this interaction means in plain words
Paracetamol and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paracetamol belongs to Musculoskeletal; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two agents that can independently injure the liver; no pharmacokinetic mechanism is established.
What to do
Keep paracetamol at low doses, within 2 g daily if possible, and monitor liver tests as required by the pexidartinib program. Stop pexidartinib per labeling if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paracetamol and Pexidartinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Paracetamol with Pexidartinib?
MediHelp rates the interaction as moderate. Paracetamol and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Paracetamol is a recognized dose-dependent hepatotoxin, so combining them may add to hepatic risk, particularly at higher paracetamol doses.
How serious is the interaction between Paracetamol and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep paracetamol at low doses, within 2 g daily if possible, and monitor liver tests as required by the pexidartinib program. Stop pexidartinib per labeling if liver enzymes rise.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
