Drug interactions
Parecoxib + Torsemide
Severity: Moderate
Parecoxib and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (via its active metabolite valdecoxib) can reduce the natriuretic and antihypertensive effects of loop diuretics and promote sodium and fluid retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Parecoxib and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and diuretic-induced natriuresis.
What to do
Monitor blood pressure, fluid status, weight and renal function, and keep the NSAID course as short as possible. Ensure adequate hydration and adjust the torsemide dose if response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Frequently asked questions
Can I take Parecoxib with Torsemide?
MediHelp rates the interaction as moderate. Parecoxib and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (via its active metabolite valdecoxib) can reduce the natriuretic and antihypertensive effects of loop diuretics and promote sodium and fluid retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
How serious is the interaction between Parecoxib and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, weight and renal function, and keep the NSAID course as short as possible. Ensure adequate hydration and adjust the torsemide dose if response is reduced.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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