Drug interactions
Parecoxib + Voriconazole
Severity: Moderate
Parecoxib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise levels of valdecoxib, the active metabolite of parecoxib, which is cleared by CYP2C9 and CYP3A4. This can increase risks of gastrointestinal, renal and cardiovascular adverse effects.
What this interaction means in plain words
Parecoxib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP2C9 and CYP3A4 metabolism of valdecoxib.
What to do
Use the lowest effective parecoxib dose for the shortest time. Monitor blood pressure, renal function and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Parecoxib with Voriconazole?
MediHelp rates the interaction as moderate. Parecoxib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise levels of valdecoxib, the active metabolite of parecoxib, which is cleared by CYP2C9 and CYP3A4. This can increase risks of gastrointestinal, renal and cardiovascular adverse effects.
How serious is the interaction between Parecoxib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest time. Monitor blood pressure, renal function and signs of GI bleeding.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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