Drug interactions
Paroxetine + Quinidine
Severity: Moderate
Paroxetine and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine strongly inhibits CYP2D6 and may raise quinidine-related effects, and quinidine can raise paroxetine levels. Paroxetine has little QT effect, but combined exposure may heighten adverse effects and arrhythmia risk.
What this interaction means in plain words
Paroxetine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Mutual CYP2D6 inhibition with possible additive effects on cardiac repolarization.
What to do
Monitor ECG and for adverse effects of either drug. Reduce doses if toxicity occurs or choose an antidepressant with less CYP2D6 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Quinidine?
MediHelp rates the interaction as moderate. Paroxetine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine strongly inhibits CYP2D6 and may raise quinidine-related effects, and quinidine can raise paroxetine levels. Paroxetine has little QT effect, but combined exposure may heighten adverse effects and arrhythmia risk.
How serious is the interaction between Paroxetine and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for adverse effects of either drug. Reduce doses if toxicity occurs or choose an antidepressant with less CYP2D6 inhibition.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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