Drug interactions
Paroxetine + Saxagliptin-metformin
Severity: Minor
Paroxetine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs, including paroxetine, have been reported to enhance glucose lowering and occasionally cause hypoglycemia in patients on antidiabetic drugs. With saxagliptin-metformin, which has low intrinsic hypoglycemia risk, the effect is generally small.
What this interaction means in plain words
Paroxetine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paroxetine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic additive effect, possibly via improved insulin sensitivity or altered counter-regulation; not well characterized.
What to do
No routine change is needed; monitor blood glucose after starting or stopping paroxetine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paroxetine and Saxagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Paroxetine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs, including paroxetine, have been reported to enhance glucose lowering and occasionally cause hypoglycemia in patients on antidiabetic drugs. With saxagliptin-metformin, which has low intrinsic hypoglycemia risk, the effect is generally small.
How serious is the interaction between Paroxetine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood glucose after starting or stopping paroxetine.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
