Drug interactions
Paroxetine + Sulindac
Severity: Moderate
Paroxetine and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine reduces platelet serotonin and impairs aggregation, while sulindac injures the gastric mucosa and inhibits platelets. Together they substantially raise the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Paroxetine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
Additive effects: SSRI-induced platelet serotonin depletion plus NSAID cyclooxygenase inhibition and mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in older patients or those with prior ulcer or anticoagulant use. Use the shortest possible NSAID course or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Sulindac?
MediHelp rates the interaction as moderate. Paroxetine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine reduces platelet serotonin and impairs aggregation, while sulindac injures the gastric mucosa and inhibits platelets. Together they substantially raise the risk of upper gastrointestinal bleeding.
How serious is the interaction between Paroxetine and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in older patients or those with prior ulcer or anticoagulant use. Use the shortest possible NSAID course or choose paracetamol.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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