Drug interactions
Paroxetine + Sumatriptan
Severity: Moderate
Paroxetine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent SSRI and sumatriptan use has been linked with rare cases of serotonin syndrome. The combination is often used in practice but requires patient awareness of the symptoms.
What this interaction means in plain words
Paroxetine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition and 5-HT1B/1D agonism.
What to do
Inform the patient about warning signs such as agitation, tremor, sweating and diarrhea. Discontinue the drugs if serotonin toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Paroxetine with Sumatriptan?
MediHelp rates the interaction as moderate. Paroxetine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent SSRI and sumatriptan use has been linked with rare cases of serotonin syndrome. The combination is often used in practice but requires patient awareness of the symptoms.
How serious is the interaction between Paroxetine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the patient about warning signs such as agitation, tremor, sweating and diarrhea. Discontinue the drugs if serotonin toxicity occurs.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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