Drug interactions
Paroxetine + Tamsulosin
Severity: Moderate
Paroxetine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a strong CYP2D6 inhibitor and can markedly increase tamsulosin exposure. This raises the risk of dizziness, orthostatic hypotension and syncope.
What this interaction means in plain words
Paroxetine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Paroxetine inhibits CYP2D6, reducing tamsulosin metabolism.
What to do
Monitor blood pressure and orthostatic symptoms, and consider a lower tamsulosin dose. Counsel patients on rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Tamsulosin?
MediHelp rates the interaction as moderate. Paroxetine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine is a strong CYP2D6 inhibitor and can markedly increase tamsulosin exposure. This raises the risk of dizziness, orthostatic hypotension and syncope.
How serious is the interaction between Paroxetine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and consider a lower tamsulosin dose. Counsel patients on rising slowly.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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