Drug interactions
paroxetine + thioridazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
QT prolongation/arrhythmia; contraindicated (label).
Mechanism of action
CYP2D6 inhibition + additive QT.
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take paroxetine with thioridazine?
The interaction is rated: Contraindicated. QT prolongation/arrhythmia; contraindicated (label).
How serious is the interaction between paroxetine and thioridazine?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between paroxetine and thioridazine managed?
Contraindicated.
Why do paroxetine and thioridazine interact?
CYP2D6 inhibition + additive QT.
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