Drug interactions
Paroxetine + Tolfenamic acid
Severity: Moderate
Paroxetine and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet function and NSAIDs such as tolfenamic acid irritate the gastric mucosa and inhibit platelet aggregation, so together they raise the risk of gastrointestinal and other bleeding. The risk is highest in older patients and those with ulcer history or concurrent anticoagulants or steroids.
What this interaction means in plain words
Paroxetine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
SSRI-induced depletion of platelet serotonin combined with NSAID COX inhibition and mucosal injury produces additive bleeding risk.
What to do
Use the shortest effective NSAID course and consider adding gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for black stools, hematemesis or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paroxetine and Tolfenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Paroxetine with Tolfenamic acid?
MediHelp rates the interaction as moderate. Paroxetine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs impair platelet function and NSAIDs such as tolfenamic acid irritate the gastric mucosa and inhibit platelet aggregation, so together they raise the risk of gastrointestinal and other bleeding. The risk is highest in older patients and those with ulcer history or concurrent anticoagulants or steroids.
How serious is the interaction between Paroxetine and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest effective NSAID course and consider adding gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for black stools, hematemesis or anemia.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
