Drug interactions
Paroxetine + Tranylcypromine
Severity: Contraindicated
Paroxetine and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine with tranylcypromine can cause fatal serotonin syndrome or hypertensive crisis. Signs include hyperthermia, rigidity, seizures and cardiovascular collapse.
What this interaction means in plain words
Paroxetine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Paroxetine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Irreversible MAO inhibition combined with serotonin reuptake blockade leads to excessive serotonin.
What to do
Never coadminister. Allow at least 14 days after stopping tranylcypromine before starting paroxetine, and at least 14 days after stopping paroxetine before starting tranylcypromine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Paroxetine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Paroxetine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Paroxetine with tranylcypromine can cause fatal serotonin syndrome or hypertensive crisis. Signs include hyperthermia, rigidity, seizures and cardiovascular collapse.
How serious is the interaction between Paroxetine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never coadminister. Allow at least 14 days after stopping tranylcypromine before starting paroxetine, and at least 14 days after stopping paroxetine before starting tranylcypromine.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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