Drug interactions
Pasireotide + Primaquine
Severity: Moderate
Pasireotide and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with bradycardia, electrolyte disturbance or underlying heart disease.
What this interaction means in plain words
Pasireotide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pasireotide belongs to Endocrine; Primaquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and repeat it during co-treatment, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Pasireotide with Primaquine?
MediHelp rates the interaction as moderate. Pasireotide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so giving them together may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with bradycardia, electrolyte disturbance or underlying heart disease.
How serious is the interaction between Pasireotide and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during co-treatment, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes markedly prolonged.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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