Drug interactions
Pasireotide + Umeclidinium-vilanterol
Severity: Moderate
Pasireotide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and slow heart rate. Vilanterol may add to arrhythmia risk through beta-adrenergic effects and lower potassium.
What this interaction means in plain words
Pasireotide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pasireotide belongs to Endocrine; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and beta-adrenergic cardiac stimulation.
What to do
Obtain a baseline ECG and monitor it, and correct potassium and magnesium during pasireotide therapy. Reassess the combination if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Pasireotide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Pasireotide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong the QT interval and slow heart rate. Vilanterol may add to arrhythmia risk through beta-adrenergic effects and lower potassium.
How serious is the interaction between Pasireotide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it, and correct potassium and magnesium during pasireotide therapy. Reassess the combination if the QTc becomes prolonged.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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