Drug interactions
Pasireotide + Vardenafil
Severity: Moderate
Pasireotide and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide and vardenafil can each prolong the QT interval, and pasireotide can cause bradycardia. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Pasireotide and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pasireotide belongs to Endocrine; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT prolongation (pharmacodynamic).
What to do
Monitor ECG and correct potassium and magnesium; avoid in patients with congenital long QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Pasireotide with Vardenafil?
MediHelp rates the interaction as moderate. Pasireotide and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide and vardenafil can each prolong the QT interval, and pasireotide can cause bradycardia. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Pasireotide and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium; avoid in patients with congenital long QT.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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