Drug interactions
Pazopanib + Quinidine
Severity: Major
Pazopanib and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Pazopanib is also associated with hepatotoxicity, and quinidine may influence its exposure through CYP3A4 and P-glycoprotein.
What this interaction means in plain words
Pazopanib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pazopanib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with possible pharmacokinetic increases in pazopanib exposure via CYP3A4 and P-glycoprotein inhibition.
What to do
Avoid the combination if possible. If necessary, obtain a baseline ECG, monitor ECG and electrolytes (potassium, magnesium) periodically, and correct abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Quinidine?
MediHelp rates the interaction as major. Pazopanib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Pazopanib is also associated with hepatotoxicity, and quinidine may influence its exposure through CYP3A4 and P-glycoprotein.
How serious is the interaction between Pazopanib and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, obtain a baseline ECG, monitor ECG and electrolytes (potassium, magnesium) periodically, and correct abnormalities.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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