Drug interactions
Pazopanib + Ritonavir
Severity: Major
Pazopanib and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 and P-gp inhibitor and can raise pazopanib concentrations. This increases the risk of hepatotoxicity, QT prolongation and other dose-related adverse effects.
What this interaction means in plain words
Pazopanib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pazopanib belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4 and P-gp, reducing pazopanib clearance.
What to do
Avoid the combination or use an alternative antiretroviral. If it cannot be avoided, reduce pazopanib to 400 mg daily and monitor liver tests, ECG and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Pazopanib with Ritonavir?
MediHelp rates the interaction as major. Pazopanib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir is a strong CYP3A4 and P-gp inhibitor and can raise pazopanib concentrations. This increases the risk of hepatotoxicity, QT prolongation and other dose-related adverse effects.
How serious is the interaction between Pazopanib and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or use an alternative antiretroviral. If it cannot be avoided, reduce pazopanib to 400 mg daily and monitor liver tests, ECG and tolerability.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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