Drug interactions
Pazopanib + Sarecycline
Severity: Minor
Pazopanib and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may modestly increase pazopanib exposure by inhibiting its efflux. Clinical relevance is uncertain given sarecycline's use in acne and low systemic exposure.
What this interaction means in plain words
Pazopanib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pazopanib belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Sarecycline is a P-glycoprotein inhibitor in vitro, reducing efflux of pazopanib.
What to do
Monitor for pazopanib adverse effects such as hepatotoxicity and hypertension. Reduce the dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Pazopanib with Sarecycline?
MediHelp rates the interaction as minor. Pazopanib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may modestly increase pazopanib exposure by inhibiting its efflux. Clinical relevance is uncertain given sarecycline's use in acne and low systemic exposure.
How serious is the interaction between Pazopanib and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pazopanib adverse effects such as hepatotoxicity and hypertension. Reduce the dose if toxicity occurs.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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