Drug interactions
Pazopanib + Simvastatin
Severity: Moderate
Pazopanib and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1 and can raise simvastatin exposure, and the combination has been associated with a higher frequency of ALT elevations. Both hepatotoxicity and myopathy are therefore concerns.
What this interaction means in plain words
Pazopanib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Pazopanib inhibits OATP1B1 and possibly CYP3A4, increasing simvastatin exposure, with additive hepatic effects.
What to do
Monitor liver function tests regularly and watch for muscle symptoms. Consider a different statin or holding simvastatin if ALT rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Simvastatin?
MediHelp rates the interaction as moderate. Pazopanib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits OATP1B1 and can raise simvastatin exposure, and the combination has been associated with a higher frequency of ALT elevations. Both hepatotoxicity and myopathy are therefore concerns.
How serious is the interaction between Pazopanib and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly and watch for muscle symptoms. Consider a different statin or holding simvastatin if ALT rises.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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