Drug interactions
Pazopanib + Umeclidinium-vilanterol
Severity: Moderate
Pazopanib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is associated with QT prolongation and torsades de pointes. Vilanterol may add to cardiac repolarization effects, particularly if potassium is low.
What this interaction means in plain words
Pazopanib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-agonist effects on potassium.
What to do
Monitor ECG and electrolytes at baseline and periodically. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Pazopanib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is associated with QT prolongation and torsades de pointes. Vilanterol may add to cardiac repolarization effects, particularly if potassium is low.
How serious is the interaction between Pazopanib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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