Drug interactions
Pegcetacoplan + Upadacitinib
Severity: Major
Pegcetacoplan and Upadacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegcetacoplan inhibits complement C3, which impairs defense against encapsulated bacteria. Adding upadacitinib's broader immunosuppression may further raise the risk of serious infections.
What this interaction means in plain words
Pegcetacoplan and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pegcetacoplan belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive impairment of host defence from complement C3 inhibition and JAK inhibition.
What to do
Ensure required vaccinations and antibiotic prophylaxis for pegcetacoplan are in place, and monitor closely for infection. Reassess the need for upadacitinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Pegcetacoplan with Upadacitinib?
MediHelp rates the interaction as major. Pegcetacoplan and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pegcetacoplan inhibits complement C3, which impairs defense against encapsulated bacteria. Adding upadacitinib's broader immunosuppression may further raise the risk of serious infections.
How serious is the interaction between Pegcetacoplan and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure required vaccinations and antibiotic prophylaxis for pegcetacoplan are in place, and monitor closely for infection. Reassess the need for upadacitinib.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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